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    <Journal>
      <PublisherName>revista-medicina-scolara</PublisherName>
      <JournalTitle>The Journal of School and University Medicine</JournalTitle>
      <PISSN/>
      <EISSN/>
      <Volume-Issue>Volume 10, Issue 1</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season> January-March 2023</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>-0001</Year>
        <Month>11</Month>
        <Day>30</Day>
      </PubDate>
      <ArticleType>Medical</ArticleType>
      <ArticleTitle>DELAYED DIAGNOSIS OF CYSTIC FIBROSIS. OPTIMISTIC OUTLOOK FOR THE NEXT DECADES. A LITERATURE REVIEW AND CASE REPORT</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>5</FirstPage>
      <LastPage>12</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Camelia-Aurora</FirstName>
          <LastName>Biciusca</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI>10.51546/JSUM.2023.10101</DOI>
      <Abstract>Cystic fibrosis (Mucoviscidosis), although classified as a rare disease, is the most common monogenic disease with autosomal recessive transmission in the Caucasian population. The average incidence for Europe is 1/2500 births. It is caused by mutations in the gene that produces the CF transmembrane conductance regulator protein (CFTR) - Cystic Fibrosis Transmembrane Conductance Regulator, which is responsible for regulating the flow of salt and fluids in the cell and results in the accumulation of viscous mucus in the lumen of the airways and damage to almost all exocrine glands.&#13;
&#13;
The clinical picture is variable, the typical form being characterized by the triad: steatorrhea, weight stagnation and respiratory manifestations. The classic form is diagnosed around the age of two, but there are also atypical forms, with an incomplete clinical-biological picture and mild evolution, which can remain undiagnosed for a longer period of time. However, they are not excluded from a good recovery and stabilization, with a good prognosis in the medium and long term. The condition is a correct management of the disease, by placing the patient under the strict monitoring of a multidisciplinary team of specialists, as well as by ensuring access to treatment.&#13;
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This presentation aims to highlight the causes that can determine a delayed diagnosis of CF, the major importance of the existence of multidisciplinary teams in diagnostic and treatment centers for CF, as well as the development of effective means of treatment both in Europe and in Romania. CF is no longer an incurable and disabling disease, patients can live a normal life, looking optimistically towards a distant future.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>Cystic fibrosis, delayed diagnosis, multidisciplinary team, optimistic outlook (prognosis)</Keywords>
      <URLs>
        <Abstract>https://www.revista-medicina-scolara.ro/ubijournal-v1copy/journals/abstract.php?article_id=14406&amp;title=DELAYED DIAGNOSIS OF CYSTIC FIBROSIS. OPTIMISTIC OUTLOOK FOR THE NEXT DECADES. A LITERATURE REVIEW AND CASE REPORT</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
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