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      <JournalTitle>The Journal of School and University Medicine</JournalTitle>
      <Volume-Issue>Volume 5 Issue 3</Volume-Issue>
      <Season>July 2018</Season>
      <ArticleTitle>The influence of psychosocial stress in the early childhood on physical and mental health in adulthood</ArticleTitle>
          <FirstName>Dr. Corina</FirstName>
      <Abstract>There is a growing interest in studying the consequences of psychosocial stress in early childhood on physical and mental health during life. When stress acts during sensitive developmental periods, it will set a pro-inflammatory cellular response that can persist over the lifecourse. Toxic stress disrupts brain development, some regions of the developing brain are heavier affected, especially the amygdala, the hippocampus and the prefrontal cortex. Hormonally, early stress confers altered patterns of endocrine and autonomic functioning. There is compelling evidence about the link between adverse childhood experiences and unhealthy lifestyle in adulthood, that lead to a wide range of chronic degenerative conditions and mental disorders. In the absence of awareness and preventive and therapeutic interventions, there is an intergenerational cycle of adversity. There is a need for widespread strategies, services and policies guided by current child development research to reduce the effects of childhood toxic stress.</Abstract>
      <Keywords>stress, childhood adversities, cerebral functioning, adult disease</Keywords>
        <Abstract>https://www.revista-medicina-scolara.ro/ubijournal-v1copy/journals/abstract.php?article_id=9285&amp;title=The influence of psychosocial stress in the early childhood on physical and mental health in adulthood</Abstract>
        <References>. Dong M, Giles WH, Felitti VJ, Dube SR, Williams JE, Chapman DP, Anda RF. Insights into causal pathways for ischemic heart disease: adverse childhood experiences study. Circulation. 2004;110(13):1761-6&#13;
2. Dube SR, Fairweather D, Pearson WS, Felitti VJ, Anda RF, Croft JB. Cumulative childhood stress and autoimmune diseases in adults. Psychosom Med. 2009; 71(2):243-50&#13;
3. Anda RF, Dong M, Brown DW, Felitti VJ, Giles WH, Perry GS, Valerie EJ, Dube SR. The relationship of adverse childhood experiences to a history of premature death of family members. BMC Public Health. 2009;9(1):106&#13;
4. Kessler RC, McLaughlin KA, Green JG, Gruber MJ, Sampson NA, Zaslavsky AM,et al. Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys. Br J Psychiatry 2010;197(5):378-85&#13;
5. Miller GE, Chen E,  Parker K. Psychological Stress in Childhood and Susceptibility to the Chronic Diseases of Aging: Moving Towards a Model of Behavioral and Biological Mechanisms. Psychol Bull. 2011;137(6): 959–997.&#13;
6. Cottrell EC, Seckl JR. Prenatal stress, glucocorticoids and the programming of adult disease. Front Behav Neurosci. 2009;3(1):19&#13;
7. Arata CM, Langhinrichsen-Rohling J, Bowers D, O’Brien N. Differential correlates of multi-type maltreatment among urban youth. Child Abuse and Neglect. 2007;31(4):393–415&#13;
8. Slopen N, Lewis TT, Gruenewald TL, Mujahid MS, Ryff CD, Albert MA, et al. Early life adversity and inflammation in African Americans and whites in the midlife in the United States survey. Psychosomatic Medicine 2010;72(7):694–701&#13;
9. McGowan PO, Sasaki A, D’Alessio AC, Dymov S, Labonte B, Szyf M, et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience 2009;12(3):342–348&#13;
10. National Scientific Council on the Developing Child. Excessive Stress Disrupts the Architecture of the Developing Brain: Working Paper #3. Available at: developingchild.harvard.edu/resources/reports_and_working _papers/. &#13;
11. Felitti VJ, Anda RF, Nordenberg D, et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. Am J Prev Med. 1998;14(4):245–258&#13;
12. McEwen BS. Protective and damaging effects of stress mediators: central role of the brain. Dialogues Clin Neurosci. 2006;8(4):367–381&#13;
13. McEwen BS, Gianaros PJ. Stress- and allostasis-induced brain plasticity. Annu Rev Med.2011;62:431–445&#13;
14. Korosi A, Shanabrough M, McClelland S, Liu ZW, Borok E, Gao XB, et al. Early-life experience reduces excitation to stress-responsive hypothalamic neurons and reprograms the expression of corticotropin-releasing hormone. Journal of Neuroscience 2010;30(2):703–713. doi: 10.1523/JNEUROSCI.4214-09.2010.&#13;
15.Tottenham N, Hare TA, Quinn BT, et al. Prolonged institutional rearing is associated with atypically large amygdala volume and difficulties in emotion regulation. Dev Sci. 2010;13(1):46–61&#13;
16. Gianaros PJ, Horenstein JA, Hariri AR, Sheu LK, Manuck SB, Matthews KA, et al. Potential neural embedding of parental social standing. Social Cognitive and Affective Neuroscience 2008;3(2):91–96&#13;
17. Fuligni AJ, Telzer EH, Bower J, Cole SW, Kiang L, Irwin MR. A preliminary study of daily interpersonal stress and C-reactive protein levels among adolescents from Latin American and European backgrounds. Psychosomatic Medicine 2009;71(3):329–333 &#13;
18. Kiecolt-Glaser JK. Stress, food, and inflammation: psychoneuroimmunology and nutrition at the cutting edge. Psychosomatic Medicine. 2010;72(4):365–369&#13;
19. Boyce WT, Ellis BJ.  Biological sensitivity to context: I. An evolutionary-developmental theory of the origins and functions of stress reactivity. Dev Psychopathol. 2005;17(2):271–301&#13;
20. Lupien SJ, McEwen BS, Gunnar MR, Heim C. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nature Reviews Neuroscience 2009;10:434–445 &#13;
21. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436–444&#13;
22. Chung HY, Cesari M, Anton S, Marzetti E, Giovannini S, Seo AY, et al. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev. 2009;8(1):18–30&#13;
23. Gillespie CF, Phifer J, Bradley B, Ressler KJ. Risk and resilience: genetic and environmental influences on development of the stressresponse. Depress Anxiety. 2009;26(11):984-92&#13;
24. Shonkoff JP, Boyce WT, McEwen BS. Neuroscience, molecular biology, and the childhood roots of health disparities: building a new framework for health promotion and disease prevention. JAMA. 2009;301(21):2252–2259&#13;
25. Rothman EF, Edwards EM, Heeren T, Hingson RW. Adverse childhood experiences predict earlier age of drinking onset: results from a representative US sample of current or former drinkers. Pediatrics. 2008;122(2)&#13;
26. Anda RF, Felitti VJ, Bremner JD, et al. The enduring effects of abuse and related adverse experiences in childhood. A convergence of evidence from neurobiology and epidemiology. Eur Arch Psychiatry Clin Neurosci. 2006;256(3):174–186&#13;
27. Scherrer JF, Xian H, Kapp JM, et al. Association between exposure to childhood and lifetime traumatic events and lifetime pathological gambling in a twin cohort. J Nerv Ment Dis. 2007;195(1):72–78&#13;
28. Braveman P, Barclay C. Health disparities beginning in childhood: a life-course perspective. Pediatrics. 2009&#13;
29. Wickrama KA, Conger RD, Lorenz FO, Jung T. Family antecedents and consequences of trajectories of depressive symptoms from adolescence to young adulthood: a life course investigation. J Health Soc Behav. 2008;49(4):468–483&#13;
30. Shonkoff JP, Garner AS. The Committee On Psychosocial Aspects Of Child And Family Health, Committee On Early Childhood, Adoption and; Dependent Care, And Section On Developmental and; Behavioral Pediatrics, Siegel B,  Dobbins M, Earls M, Garner A, McGuinn L, Pascoe J, Wood D.  The lifelong effects of early childhood adversity and toxic stress.Pediatrics. 2012;129(1):e232-46.</References>