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  <Article>
    <Journal>
      <PublisherName>revista-medicina-scolara</PublisherName>
      <JournalTitle>The Journal of School and University Medicine</JournalTitle>
      <PISSN/>
      <EISSN/>
      <Volume-Issue>Volume 6 Issue 3</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>July - September 2019</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>2019</Year>
        <Month>07</Month>
        <Day>31</Day>
      </PubDate>
      <ArticleType>Medical</ArticleType>
      <ArticleTitle>INFLUENZA PROPHYLAXIS: CURRENT APPROACHES</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>5</FirstPage>
      <LastPage>13</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Bianca-Georgiana</FirstName>
          <LastName>Milcu</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Dalida-Ana</FirstName>
          <LastName>Domuncu</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Dorina-Maria</FirstName>
          <LastName>Craciun</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Daniela</FirstName>
          <LastName>Pitigoi</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Victoria Arama</FirstName>
          <LastName/>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI/>
      <Abstract>Influenza is an acute respiratory disease. It  holds a top position among infectious pathologies due  to its high morbidity and mortality, but also due to its  socio-economic implications.  &#13;
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Apart from personal prevention measures, the  prevention of infl uenza also includes vaccination and  prophylaxis with antivirals. The aim is to present the  current methods aimed at preventing seasonal infl u &#13;
&#13;
enza epidemics.  &#13;
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We have reviewed the specifi c literature, the  infl uenza guidelines and recommendations.  The infl uenza vaccination is the most effective  way to prevent the disease; until the development  of universal infl uenza vaccine, the efforts of physi cians, researchers and policy-makers should focus on  increasing vaccination coverage, especially among  &#13;
&#13;
Infl uenza is an acute respiratory infection that  recurs annually to the attention of medical specialists  due to its increased morbidity, complications, excess  mortality, but also due to its socio-economic implica &#13;
&#13;
tions [1,2].  &#13;
&#13;
Annually, the World Health Organization  (WHO) reports 3-5 million fl u illnesses and 290,000- 650,000 deaths. Children, elderly, pregnant women,  chronic and immunodepressed patients are the most  severely affected [1,3]. &#13;
&#13;
Infl uenza generates signifi cant yearly economic  costs due to workplace absenteeism, socio-economic  disruption, medical care costs [1]. &#13;
&#13;
Infl uenza can be prevented or controlled  through general measures to prevent respiratory  &#13;
&#13;
vaccines formulation and delivery, as well as on the  training of medical professionals and population.  For preventing infl uenza illnesses, pre-expo sure or post-exposure prophylaxis with antivirals can  be considered but it depends on several factors such as  costs, compliance, side effects and the most important  thing, the risk of emerging antiviral-resistant strains.  Nowadays, neuraminidase inhibitors such as  oseltamivir and zanamivir are used for infl uenza chem oprophylaxis. In some countries, new antiviral agents  (Baloxavir marboxil and Laninamivir) are available.  The antiviral agents mustn’t replace the infl u enza vaccine and mustn’t decrease the acceptability  rate of infl uenza vaccination.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>influenza, prophylaxis, antivirals,  vaccination</Keywords>
      <URLs>
        <Abstract>https://www.revista-medicina-scolara.ro/ubijournal-v1copy/journals/abstract.php?article_id=9267&amp;title=INFLUENZA PROPHYLAXIS:  CURRENT APPROACHES</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
        <References>1. Ivan A. Tratat de epidemiologie a bolilor transmisibile.  Ed. Polirom Bucure?ti 2002 &#13;
&#13;
2. Miron VD, Dr?g?nescu AC, Luminos ML, Streinu-Cer cel A, S?ndulescu O. (coord.). Epidemiologia ?i etiopatogenia  gripei ?i a coloniz?rii pneumococice la copil-aspecte clinice, par aclinice ?i microbiologice. Ed. Sigma Bucure?ti 2018 &#13;
&#13;
3. World Health Organisation. A Manual for Estimating  Disease Burden Associated With Seasonal Infl uenza, accesat  12.12.2018, disponibil online https://apps.who.int/iris/bitstream/ handle/10665/178801/9789241549301_eng.pdf;jsession id=446CE7BA34EDD9A10B18E3590E3E7034?sequence=1 &#13;
&#13;
4. Centrul Na?ional de Supraveghere ?i Control al Bo lilor Transmisibile. Metodologia de supraveghere a gripei,  infec?iilor respiratorii acute (ARI) ?i a infec?iilor respira torii acute severe (SARI), accesat 12.02.2019, disponibil  online https://www.cnscbt.ro/index.php/metodologii/gri pa-infectii-acute-respiratorii-si-sari/765-metodologia-de-su praveghere-gripa-infectii-respiratorii-acute-si-sari-2017-2018/ fi le &#13;
&#13;
5. Ong AK, Hayden FG, John F. Enders lecture 2006: an tivirals for infl uenza. J Infect Dis. 2007;196(2):181-190  6. Bennett JE, Dolin R, Blaser MG. Mandell, Douglas,  and Bennett’s Principles and Practice of Infectious Diseases,  Eighth Edition. 2015;Vol 2. Elsevier Saunders  &#13;
&#13;
7. Robesyn E, Broberg E, Kramarz P. Expert opinion on  neuraminidase inhibitors for the prevention and treatment of in fl uenza-Review of recent systematic reviews and meta-analyses.  European Center for Disease Prevention and Control, Stockholm  2017 &#13;
&#13;
8. Wang K, Shun-Shin M, Gill P, Perera R, Harnden A.  Neuraminidase inhibitors for preventing and treating infl uenza in  children. Cochrane Database Syst Rev. 2014;(4)  &#13;
&#13;
9. Okoli GN, Otete HE, Beck CR, Nguyen-Van-Tam JS.  Use of neuraminidase inhibitors for rapid containment of infl u enza: a systematic review and meta-analysis of individual and  household transmission studies. PLoS One 2014;9(12) &#13;
&#13;
10. Nishiura H, Oshitani H. Household Transmission of  Infl uenza (H1N1-2009) in Japan: Age-Specifi city and Reduction  of Household Transmission Risk by Zanamivir Treatment. J Int  Med Res. 2011;39(2):619-628 &#13;
&#13;
11. Peters PH, Gravenstein S, Norwood P, Ward P.  Long-term use of oseltamivir for the prophylaxis of infl u enza in a vaccinated frail older population. J Am Geriatr Soc.  2001;49(8):1025-1031 &#13;
&#13;
12. Ison MG, Szakaly P, Shapira MY, Krivand;aacute;n G, Nist  A, Dutkowski R. Effi cacy and safety of oral oseltamivir for  infl uenza prophylaxis in transplant recipients. Antivir Ther.  2012;17(6):955-964 &#13;
&#13;
13. Kashiwagi S, Watanabe A, Ikematsu H, Uemori M,  Awamura S. Laninamivir Prophylaxis Study Group. Long-acting  Neuraminidase Inhibitor Laninamivir Octanoate as Post-exposure  Prophylaxis for Infl uenza. Clin Infect Dis. 2016;63(3):330-337 &#13;
&#13;
14. Mossad SB. Infl uenza update 2018–2019: 100 years  after the great pandemic., Cleve Clin J Med. 2018;85(11):861-869 15. Open Chemistry Database. Baloxavir Marboxil, dis ponibil online https://pubchem.ncbi.nlm.nih.gov/compound/Ba loxavir_marboxil, accesat 17.02.2019 &#13;
&#13;
16. Sullivan GS, Price HO, Reagan A. Burden, effec tiveness and safety of infl uenza vaccines in elderly, paedriatic  and pregnant populations, Ther Adv Vaccines Immunother.  2019;7:1-16 &#13;
&#13;
17. European Center for Disease Prevention and Con trol. WHO recommendations for infl uenza virus vaccine com position for the 2019–2020 northern hemisphere season, accesat  10.03.2019, disponibil online https://ecdc.europa.eu/en/news events/who-recommendations-infl uenza-virus-vaccine-composi tion-2019-2020-northern-hemisphere &#13;
&#13;
18. Skowronski DM, Leir S, Sabaiduc S, Murti M, Dick inson JA, Olsha R, Gubbay JB, Croxen MA, Charest H, Chan T,  Bastien N, Li Y, Krajden M, De Serres G. Interim estimates of  2018/19 vaccine effectiveness against infl uenza A(H1N1)pdm09,  Canada. Euro Surveill. 2019;24(4) &#13;
&#13;
19. Cernescu C. Gripa-studiu critic. Ed. Academiei  Romand;acirc;ne. Bucure?ti 2007  &#13;
&#13;
20. Centers for Diseases Control and Prevention, Infl u enza (Flu), accesat 17.02.2019, disponibil online https://www. cdc.gov/fl u/professionals/vaccination/vaccine_safety.htm &#13;
&#13;
21. Navarro-Torne A, Hanrahan F, Kerstiand;euml;ns B, Aguar P,  Matthiessen L. Public Health-Driven Research and Innovation for  Next-Generation Infl uenza Vaccines, European Union. Emerging  Infectious Diseases 2019;25(2) &#13;
&#13;
22. Centrul Na?ional de Supraveghere ?i Control al Bo lilor Transmisibile, Sezonul gripal 2016-2017 (prezentare), ac cesat 10.03.2019, disponibil online http://www.cnscbt.ro/index. php/prezentari/rodica/785-analiza-sezon-gripal-2016-2017/fi le &#13;
&#13;
23. Barney SG. Universal Infl uenza Vaccines (prezentare),  accesat 25.03.2019, disponibil online https://www.who.int/immu nization/research/meetings_workshops/23_Universal_fl u.pdf</References>
      </References>
    </Journal>
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